The initial proof of concept studies in human heart cells and engineered heart tissue showed that the gene-vector-promoter construct corrects MyBP-C protein levels/expression in the sarcomere and ...

Another project in the lab seeks to identify additional possible molecules that help to arrange and maintain the appropriate myosin heavy chain protein shape and aid its incorporation into the ...

HCM is inherited as a mendelian autosomal dominant trait and caused by mutations in any one of 11 genes, each encoding proteins of the cardiac sarcomere. It has an incidence of 1 in 500 of the general ...

In the cardiovascular system, AS of transcripts of sarcomere, ion channel, and cell signaling protein genes, as well as long ...

The novel cardiac myosin inhibitor aficamten improved ... blocker use and independent of the presence of a pathogenic sarcomere gene variant," the researchers noted. Among the secondary endpoints ...

and an increased risk of sudden cardiac death. It is caused by mutations in sarcomere protein genes, leading to altered cell metabolism, including oxidative stress and mitochondrial dysfunction.

Illustration of the interacting thick and thin filaments in the cardiac sarcomere based on structural cryo electron-tomography data. Credit MPI of Molecular Physiology ...

EDG-7500 is a novel oral, selective, cardiac sarcomere modulator, specifically designed to slow early contraction velocity and address impaired cardiac relaxation associated with HCM without ...