The 2006 Ford E350 has an average reliability rating of 4.7 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2006 E350 owners.

305.0-hp, 6.8-liter, 10 Cylinder Engine (Gasoline Fuel) $0 Starting MSRP Wondering which trim is right for you? Our 2006 Ford E350 Super Duty trim comparison will help you decide.