They also showed that a low dose of carvedilol (e.g., <25 mg per day) is as effective as higher doses (e.g., 25–50 mg per day) at decreasing HVPG, with a lower risk of causing arterial hypotension.

Carvedilol has the capacity to block both the β-1 and β-2 adrenergic receptors, as well as the α-1 receptors. There is evidence to indicate that full adrenergic blockade by carvedilol improves ...

Maximum plasma concentrations of carvedilol occur 1-2 hours after oral administration. [9] Absolute bioavailability of carvedilol is approximately 23% due to extensive first-pass metabolism.