Over the past 15 years, developments in the gene-editing technique known as CRISPR-Cas9 have produced significant new ...

The Cas9 protein is the most widely used by scientists. This protein can easily be programmed to find and bind to almost any desired target sequence, simply by giving it a piece of RNA to guide it ...

In their new work, to find novel programmable systems, the team began by zeroing in on a structural feature of the CRISPR Cas9 protein that binds to the enzyme's RNA guide. That is a key feature ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

Antibiotic resistance is a global concern that threatens our ability to prevent and treat bacterial infections in humans and animals. To better monitor the emergence and spread of resistance, ...

Protein design (or protein engineering ... Domain expansion contributes to diversification of RNA-guided endonucleases including Cas9. Here, authors succeed in enlarging the noncatalytic REC ...

But to date this technology - which allows scientists to use a "guide" RNA to modify DNA sequences and evaluate the effects - ...

CRISPR-Cas9 is not the first method available to scientists for modifying DNA ... The design of such enzymes that can recognize longer DNA sequences is particularly complex, however, as DNA ...

Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, ...