Then they mapped single-cell lineage output to gene expression against a cDNA library to generate a molecular bridge database. Lu and her team used the database to quantify HSC lineage outputs across ...

Cell lineage and determination are terms heavy with significance for developmental biologists because they are the central concepts underpinning the process of regional specification—the ...

Historically, cell lineage tracing studies have taken large pools of cells from mature tissues and inferred their origins retrospectively by staining the cells with vital dyes or transplanting ...