Figure 2: Retinoblastoma protein and cell-cycle progression. Recent experiments have implicated one specific E2F target, CDC6, as a potentially important marker for quiescence. CDC6 has a crucial ...

E2F contributes to the cell cycle-dependent transcription of a multitude of genes involved in DNA synthesis and cell proliferation. "This work is an effort to understand how the activity of E2F is ...

The product of this tumor suppressor gene, a 105-kilodalton polypeptide called pRB, `is a cell cycle regulator. The pRB polypeptide inhibits cell proliferation by arresting cells at the G1 phase of ...

2013;8(3):323-352. p53 In vitro using GST-fused proteins and coimmunoprecipitation using both ectopically expressed as well as EBV-transformed cells Blocks p53-dependent transcriptional activation ...