Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic barrier against tumorigenesis and a mechanism contributing to organismal ageing. Unexpected findings now ...

Gut microbiota-derived phenylacetylglutamine accelerates aging by driving cellular senescence through mitochondrial ...

The research focuses on cellular senescence, a process where cells stop ... By targeting the ACLY-BRD4 pathway, the ...

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme ubiquitously present in all living cells, playing a pivotal ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...