A recent study published in Life Metabolism reports that high temperature can ameliorate insulin resistance by promoting ceramide catabolism in skeletal muscle tissue (SMT) of obese mice.

IR was associated with decreased levels of phospholipids [125] Insulin resistance 13 obese T2D and 14 lean healthy control subjects Plasma ceramides are elevated in obese subjects with T2D and ...

We recently reported that insulin resistance is not generally normalized ... content and reductions in IMTG and intramyocellular ceramide but not DAG. RYGB surgery–induced weight loss enhanced ...