为探究阿尔茨海默病（AD）发病机制，首都医科大学宣武医院神经疾病创新中心等机构的研究人员开展了深入研究。聚焦 mtDNA - cGAS - STING 通路，他们的研究成果发表在《Molecular Neurodegeneration》上，为我们认识 AD 提供了新的视角，也为治疗 AD 带来了新的希望。

目前，激活关键的先天免疫通路成为增强抗肿瘤免疫反应的重要策略，其中环鸟苷酸 - 腺苷酸合成酶 - 干扰素基因刺激蛋白（cGAS-STING）通路备受关注。该通路可被胞质 DNA 识别激活，进而触发 I 型干扰素（IFN-I）的产生，启动先天免疫反应，同时还能促进适应性 ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

那在对抗癌症时，像cGAS-STING这样重要的免疫应答通路，按说当然也得严加防范，但偏偏就有研究显示，癌细胞竟然能设法避免cGAS-STING通路的免疫 ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Triggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses ...

Because cGAS was the only candidate that produced cGAMP activity, this finding solidified its place as the elusive cytosolic DNA sensor to complete the cGAS-cGAMP-STING pathway. “It was quite a ...

A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighbouring and immune cells by secondary ...

"With the discovery and mapping of the cGAS-STING signaling pathway, the award winners have opened up completely new approaches to drug research," explains Thomas Boehm, Chairman of Paul Ehrlich ...