The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

Triggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses ...

this finding solidified its place as the elusive cytosolic DNA sensor to complete the cGAS-cGAMP-STING pathway. “It was quite a surprise that this sensor turned out to be an enzyme,” said Chen.

A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighboring immune cells by secondary messengers ...

This triggers the cGAS-STING pathway, a major immune response mechanism that typically fights infections. Under normal ...

Ateganosine, also known as 6-thio-2'-deoxyguanosine, works by inducing telomerase-dependent telomeric DNA modification and activating immune responses, including the innate cGAS/STING pathway and ...