这篇综述聚焦癌症免疫中 cGAS-STING 通路，深入剖析其激活免疫反应、发挥抗肿瘤作用的机制，探讨在癌症治疗中的应用、STING 激动剂的研发进展，分析面临的挑战，为癌症免疫治疗提供新思路，文章发表在《Journal of Hematology & Oncology 》上值得一读。 癌症免疫中的 ...

为探究 STX12 缺乏的病理生理改变及致死机制，研究人员构建 Stx12 基因敲除小鼠和敲低斑马鱼模型开展研究。结果发现 STX12 缺失导致线粒体损伤、mtDNA 释放，激活 cGAS-STING 通路和炎症反应，这为揭示相关疾病机制提供了新视角。

The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

Triggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses ...

"With the discovery and mapping of the cGAS-STING signaling pathway, the award winners have opened up completely new approaches to drug research," explains Thomas Boehm, Chairman of Paul Ehrlich ...

Because cGAS was the only candidate that produced cGAMP activity, this finding solidified its place as the elusive cytosolic DNA sensor to complete the cGAS-cGAMP-STING pathway. “It was quite a ...

A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighboring immune cells by secondary messengers ...