If Pnkp and Rnl1 are not present, depletion of the pool of functional tRNA Lys by PrrC blocks phage protein synthesis and arrests the infection before it can spread. However, Pnkp and Rnl1 repair the ...

Despite their crucial role in a core function of life, we are only beginning to understand the vast implications of tRNA modification and the complexity of the underlying mechanisms. We know that in ...

Defects in tRNA biology, such as mutations in tRNA genes or aminoacyl-tRNA synthetases, can lead to various diseases, including: Understanding the mechanisms of tRNA-related diseases and the potential ...