Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids ...

Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

A diverse complement of amino acids are conjugated to bile acids by bacteria, and the resulting MCBAs have very different chemical properties. For example, we have evidence that if bacteria use a ...

A recent study explores one fascinating aspect of this partnership: how gut bacteria team up with the host body to regulate ...

Bile acids help the digestive system break down ... Thompson Institute and a professor in the Department of Chemistry and ...