CD19-directed chimeric antigen receptor (CAR) T cells are clinically effective in a limited set of leukemia patients. However, CAR T-cell therapy thus far has been largely restricted to targeting ...

Despite advances in conventional treatment modalities, patients with metastatic CRC often face limited options and poor outcomes. Chimeric antigen receptor-T (CAR-T) cell therapy, initially successful ...

Chimeric Antigen Receptor (CAR) T-cells for immunotherapy of cancer are being developed. These CAR T-cells overcome several limitations of current strategies including the ability to tune CAR T-cell ...