本研究聚焦胃癌化疗耐药难题，揭示ADAM9通过激活ATM-CHK2通路增强DNA修复，导致胃癌细胞对顺铂耐药，为克服化疗耐药提供新靶点 胃癌是全球最常见的恶性肿瘤之一，化疗耐药的发生严重影响中晚期患者的生存和预后。增强DNA修复能力是化疗耐药的重要机制之一。

为探究缺氧肿瘤微环境中 HIF-1α 的调控机制，研究人员发现 ROS-ATM-CHK2 轴稳定 HIF-1α 促进肿瘤血管生成，为抗血管生成疗法提供理论依据。 在肿瘤的世界里，缺氧是一个极为常见且关键的 “角色”。肿瘤在生长过程中，随着体积不断增大，内部的细胞逐渐难以 ...

Conversely, despite the fact that the NHEJ pathway was not identified through classical genetic approaches in the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae, it is now known ...

it halted progression at the S phase through the ATR/Chk1 pathway, while in HCT-116 cells, it caused arrest at the G1 phase via the ATM/Chk2 pathway. This was accompanied by downregulation of key ...

it halted progression at the S phase through the ATR/Chk1 pathway, while in HCT-116 cells, it caused arrest at the G1 phase via the ATM/Chk2 pathway. This was accompanied by downregulation of key ...