How is all of that DNA packaged so tightly into chromosomes and squeezed ... (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs ...

Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin ... histone proteins are associated with each nucleosome to maintain the ...

We are interested in the mechanism of chromosome replication ... positions and histone modifications are critical determinants of a cell’s gene expression program and, therefore, cell identity.

SCFAs, such as propionate and butyrate, derived from dietary fiber metabolism, serve as substrates for histone acylation and exhibit antiproliferative effects in cancer by altering chromatin ...

This course provides and overview of epigenetic mechanisms, including DNA methylation, histone modifications, chromosome structure, and nuclear organization. We will discuss how molecules help ...

To convert a piece of cloned DNA into a centromere-containing human artificial chromosome (HAC), an array of repeated LacO sequences ... The fusion protein binds to the LacO domains (1), and ...