The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA (Van Holde, 1988; Wolffe, 1999).

Chromatin remodeling plays a vital role in ... shape to test the significance of particular movements to the protein's function. This work allowed them to tease out previously conflicting ...

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on ...

Scientists at the Icahn School of Medicine at Mount Sinai have discovered a possible reason why some cases of melanoma—a ...

The Dere lab specializes in kidney cancer and VHL (von Hippel Lindau) disease focused on understand fundamental aspects of how non-chromatin functions of chromatin modifiers contribute to oncogenesis.

We study all of the protein components of chromatin with an emphasis on understanding how multiple sources of variation function in concert or combination with each other. A major, but not exclusive ...

He developed an innovative method to extract chromatin with a specific mark and uses a specialized type of microscopy, called cryogenic electron microscopy (or cryo-EM) to visualize it. Dr. Arimura’s ...

In a collaboration with Michael Snyder, a functional genomicist at Stanford University who was at Yale University at the time, Jones’ team obtained chromatin immunoprecipitated DNA fragments to which ...

Moreover, we observed that expression of a chromatin regulator from an mRNA with or without its 3′UTR resulted ... specifically the 3′ untranslated region (3′UTR), can control protein activity and ...