Histone modifications alter the structure of chromatin, affecting how tightly the DNA is packaged and influence gene expression. Similarly, transcription factors, which bind to the DNA, are essential ...

Figure 1: Time- and light-dependent phosphorylation of histone H3 in the suprachiasmatic nucleus. Figure 2: Photic stimulation did not induce H3 phosphorylation in the pineal gland and in the ...

We study all of the protein components of chromatin with an emphasis on understanding how multiple sources of variation function in concert or combination with each other. A major, but not exclusive ...