To do this, they trained GET on measurements of chromatin accessibility and transcription from single cells of a human cell line known as K562. The authors benchmarked GET’s predictions against ...

Box 2 Regulation of gene expression: transcription factors and chromatin-modifying proteins. Transcription factors are proteins that translate extracellular and intracellular signals into ...

If your genes could set an alarm clock, EZH1 might be the one ringing the bell. A new study has revealed how this ...

This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to reveal mechanisms of disease. Our laboratory works at the intersection of three fields: ...

At the time, researchers were unsure whether histones in the nucleosomes dissociated or remained bound to the DNA as the chromatin uncoiled and RNA polymerase began its job transcribing genes. It was ...

Abdenour Soufi from the University of Edinburgh reveals how transcription factors (TFs)—key proteins that regulate gene activity—navigate DNA and chromatin structures to determine cellular ...

EZH1 is a key regulator of circadian rhythms, stabilizing gene transcription and modifying chromatin to maintain genetic ...

A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene ...

GET, a novel computational model, accurately predicts gene activity by analyzing chromatin accessibility and DNA sequences across diverse human cell types.

Scientists have discovered that a crucial protein found in plants, called auxin response factor (ARF) first arose about 600 ...

(acyl-CoA) availability. These modifications correlate with metabolic states, impacting chromatin accessibility and transcription. SCFAs, such as propionate and butyrate, derived from dietary ...

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on ...