Avoid other nephrotoxic drugs (eg, ciprofloxacin, gentamicin ... imatinib, nefazodone, oral contraceptives). Avoid alcohol, grapefruit juice. Cyclosporine levels decreased by CYP3A inducers ...

Purpose: The effect of omeprazole on the oral bioavailability and urinary exposure of the Depomed formulation of extended-release(ER) ciprofloxacin was studied. Methods: A two-way crossover study ...