Taken together, these results suggest that peripheral mGluRs mediate a component of hyperalgesia and may ... mGluR5 are expressed in the periphery on cutaneous primary afferents.

Some of the central molecular mechanisms that lead to hyperalgesia and allodynia after peripheral tissue injury involve the spinal dorsal horn transient receptor potential vanilloid 1 (TRPV1).

A prominent symptom of chronic pain is mechanical hyperalgesia, or increased pain ... Rubbing or massaging a painful area of the skin, which presumably activates Aβ-LTMRs, attenuated pain in ...