A study by Mellqvist et al. has assessed the efficacy and safety of combined bolus-dose cyclophosphamide and pulse-dose dexamethasone (Cy-Dex) as initial treatment for patients with myeloma.

Cyclophosphamide or mycophenolate mofetil ... 1.89-4.22), particularly at a dosage of 4 mg per day or greater (adjusted OR = 5.65; 95% CI, 2.35-13.55) and for longer than 180 days (adjusted ...