Shedding light on a decades-old protein sorting mystery
Considering that many apical membrane proteins have very short or non-existent cytoplasmic domains—meaning that most of their ...
Nature4y
Structure and signaling of Toll-like receptors
The ligand binds to a site in the extracellular domain of the receptor (not shown) and induces a conformational change that activates the cytoplasmic domains, enabling interaction and assembly of ...
Nature26d
Folding intermediates of SNARE complex assembly
Figure 1: Structural characterization of the cytoplasmic domains of uncomplexed Sso1 and Snc1. Figure 5: a, Summary of the NMR data mapping unstructured or flexible regions in the cytoplasmic ...