The groundwork to this discovery was laid in 1997 when P bodies were described, but not named, by Bashkirov et al. These authors showed that the major 5′→3′ cytoplasmic exonuclease in ...

The SMN protein localizes to both the cytoplasm and the nuclear bodies. One hallmark of spinal muscular atrophy is the failure of SMN to localize within these nuclear bodies. A recent study has ...