Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...

A new study in Engineering explores the role of astrocytic G protein-coupled receptors in drug addiction. It shows that these receptors, including ...

Theranocure Co. Ltd. has prepared and tested new vanillic acid derivatives targeting the dopamine D1 receptor (D1R) reported to be useful for the treatment of neuroinflammation and Alzheimer’s disease ...

Disruptions in the dynamic balance of D1-receptor mediated phosphorylation and dephosphorylation cascades in different regions of the neuron may lead to impaired integration of synaptic inputs.

Nearly 16 million American adults have been diagnosed with attention deficit hyperactivity disorder (ADHD), but evidence ...

Receptors can display different ligand binding properties depending on whether or not they are engaged in a receptor heteromer. The D 1-D 2 receptor heteromer provides an example of changes in ...

Fixed and flexible doses of tavapadon significantly improved motor function compared with placebo in patients with Parkinson’s disease, according to a pair of phase 3 trials presented at the American ...

Nearly 16 million American adults have been diagnosed with attention deficit hyperactivity disorder (ADHD), but evidence suggests that more than 30 percent of them don’t respond well to stimulant ...

The study specifically examines two types of GPCRs expressed on astrocytes: dopamine D1 receptors (D1R) and metabotropic ...

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