Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena have discovered a new function of the DNA repair protein ATR in regulating mitochondrial homeostasis. This discovery ...

Normal metabolic activity produces reactive oxygen species (ROS) that, if not eliminated, can damage cellular components. As a result, ROS from overactive mitochondria are frequently cited as a source ...

Harman hypothesized that these compounds, which chemists call free radicals, react with cellular components, causing damage that over ... known today as mitochondrial DNA (mtDNA).

Tardigrades produce a key damage-suppressor protein known as Dsup, which binds to their DNA to protect them from radiation. Byrne and Traverso wanted to somehow arm mice with this protein so they ...