The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

在癌症研究领域，p53 基因一直备受关注。它被称为 “基因组的守护者”，正常情况下，p53 蛋白能够在细胞 DNA 受损时发挥作用，阻止细胞异常增殖，诱导细胞周期停滞、凋亡或者 DNA 修复 ，从而抑制肿瘤的发生发展。但 p53 基因突变在多种癌症中频繁出现 ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

This is where p53 comes in. It acts like a vigilant proofreader, detecting errors in DNA and deciding how to handle them. If the damage is minor, p53 instructs the cell to repair it. But if the ...

1,2 Such responses can block aberrant growth but in some cases invariably fail. This could explain why the p53 tumor suppressor gene and other elements of the DNA damage-response pathway are so often ...

The researchers also saw significant overexpression of two gene modules in these cells: the p53 DNA damage response and general apoptosis pathways. The researchers wondered if they could find evidence ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...