Figure 1: Model of cellular senescence maintained by concerted action of several autocrine self-regulatory loops and the DNA damage response. Although still preliminary, the involvement of ...

Our data show that ADAM19 may be important in mitigating the inflammatory response to intestinal damage and cellular senescence."BUFFALO, NY — April ...

At this point, DNA repair systems recognize it as DNA damage and trigger a form of permanent cell cycle arrest called replicative senescence, which may lead to cell death called apoptosis. 5 This ...

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One possible stressor that may induce cell senescence is nuclear DNA damage, primarily in the form of DNA double-strand breaks (DSBs) that activate the DNA damage response (DDR) pathway.

Proteins that trigger cell senescence occupy much of the literature on aging, but a small RNA moves into the limelight. Kamal is a freelance science journalist based in the UK with a PhD in virology ...

Despite the higher levels of DNA damage in polyploid cells, they showed greater resistance to cisplatin than diploid cells.

Aging occurs in many ways, from our joints getting creaky to bigger problems, like dementia. Two processes are being studied for their role in aging: one is cell senescence and the other is damage to ...