ATR 激酶是应对 DNA 复制应激（RS）的关键调节因子，在癌细胞中，许多遗传突变会导致 RS 水平升高，而 ATR 在维持复制叉的稳定性和促进细胞存活方面发挥着重要作用。抑制 ATR 可使癌细胞因复制叉崩溃和有丝分裂灾难而死亡，因此 ATR 成为癌症治疗的潜在靶点。目前，基于 ATR 抑制剂（ATRi）的临床试验正在开展，但尚未建立有效的治疗方案。

In particular, there is a critical need for more effective small-molecule inhibitors of transcription factors, a major class of molecules that interact with other proteins and with DNA.

DNA gyrase inhibitors are a class of antibacterial agents that target bacterial DNA gyrase, an essential enzyme involved in DNA replication and maintenance. This enzyme is crucial for the survival ...

This strategic milestone marks Rakovina Therapeutics’ entry into one of the largest equity markets in Europe, providing increased visibility and accessibility to European and global investors. The ...

Phosphoproteomics unveils the mode of action of clinical ATR inhibitors and explains their synergy with Gemcitabine in ...

Shanghaitech University has identified thiazolidinedione compounds acting as DNA methyltransferase 3A (DNMT3A) inhibitors reported to be useful for the treatment of acute myeloid leukemia and ...

Ancient DNA studies provide critical insights into human evolution and extinct species, leveraging advanced techniques to ...

Announcing a new article publication for Zoonoses journal. Methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin ...

The targeting of telomeres offers promise for new cancer therapies, which can be aimed at disrupting the mechanisms that ...