The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

After two fragments with complementary sticky ends are joined, the DNA backbone may be covalently sealed using another enzyme called DNA ligase.

RNA repair enzymes capable of sealing 2’,3’-cyclic-PO 4 /5’-OH breaks or 3’-OH/5’-PO 4 breaks are present in diverse taxa in all phylogenetic domains of life. ATP-dependent RNA ligases join 3’-OH and ...

In the early 1950s, experiments by two teams of researchers, Salvador Luria working with Mary Human and Joe Bertani working with Jean Weigle, showed that some strains of bacteria were more ...

Causes: LIG4 syndrome is caused by a mutation in the LIG4 gene, which carries the instructions needed to make a protein known as DNA ligase 4. This protein is an enzyme that helps repair a ...