DNA can be further compressed through a twisting process called supercoiling (Figure 9). Most prokaryotes lack histones, but they do have supercoiled forms of their DNA held together by special ...

An overwound DNA exhibits positive supercoiling; an underwound DNA exhibits negative supercoiling.

This enzyme, present in bacteria but absent in humans, plays a crucial role in supercoiling DNA, a necessary process for bacterial survival. Using high-resolution cryo-electron microscopy the ...

His team set about using cryo-EM to examine how RNAP remains clamped to DNA after transcription termination, and how RapA interacts with it. They chose negatively supercoiled DNA—an underwound ...