NON-enzymatic decarboxylation of α-amino-acids was tried many years ago by heating them above 200° C., often dissolved or dispersed in an inert solvent too. As the reactions are always exotherm ...

No reaction was observed in the absence of oxygen. The identification of the decomposition products of citrate, apart from carbon dioxide, was not attempted.

Additionally, it proposes a diversity-oriented chemo-enzymatic synthesis strategy, integrating the advantages of decarboxylation functional group reactions and enzymatic D–A reactions ...