Biophysical characterization of the dystrophin C-terminal domain: Dystrophin interacts differentially with dystrobrevin isoforms. Journal of Biological Chemistry , 2024; 300 (12): 108002 DOI: 10. ...

Evox Therapeutics, a privately held biotechnology company based in Oxford, UK, is leading the way in exploiting this natural mechanism ... lack of functional dystrophin protein.

Dystrophin is part of a protein complex linking the cytoskeleton of muscle fibers to the surrounding connective tissue (basal lamina). It’s a long protein with numerous redundant coils (purple balls), ...

It is an X-linked recessive disorder that occurs due to changes in the DMD gene, which codes for the protein dystrophin. Dystrophin is a protein that plays a role in strengthening muscle fibers ...

Unlike traditional approaches that aim to replace or repair the missing dystrophin protein, K884 focuses on bolstering the natural repair mechanisms of muscle stem cells. This strategy not only ...