TAXIS has developed a novel strategy consisting of targeting bacterial efflux pumps, a family of multi-protein complexes that span the bacterial cell membranes and act like bilge pumps that flush ...

Bacteria may also produce or upregulate efflux pumps, which actively transport antibiotics out of the cell, preventing the drug from reaching its intracellular target. They may also modify the ...

Bacterial resistance to multiple antibiotics and other drugs is a major ... a constitutively expressed, major multidrug efflux system of Escherichia coli energized by proton motive force (Science, 300 ...

Efflux pumps of the resistance-nodulation-division family: a perspective of their structure, function, and regulation in gram-negative bacteria. Efflux pumps of gram-negative bacteria: genetic ...

Understanding how bacteria control the entry and efflux of chemicals helps us to explain and possibly reverse antimicrobial drug resistance. Even when antimicrobials gain access via porins, they are ...

In addition to antibiotics, bacteria also use their efflux pumps to transport toxic compounds, virulence factors, dyes, and ...

coli and H. influenzae. AcrB efflux pumps can actively transport antibiotics out of the periplasm and cytoplasm of bacterial cells, rendering them ineffective. AcrB-Ec can also export bile salts ...