The numbers in the germline vary dramatically throughout embryo, foetal and offspring development 21. About 100,000 mitochondria are estimated to be present in the mouse oocyte at the time of ...

At least one in 10,000 people in the UK are affected by diseases caused by mutations in their mitochondrial DNA (mtDNA). A new study in human embryos provides a potential route to prevent ...

Recent research is revealing that the earliest stages of human development, even before birth, may hold the key to predicting ...

In cytoplasmic hybrid embryos, all the DNA in the cell nucleus is human. The remaining animal DNA is found only in the mitochondria, which are small rod-shaped organelles found outside the nucleus ...

Zhou, Q.H., Li, H.M., and Xue, D. (2011). Elimination of Paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Research 21, 1662-1669 ...

In PT, the two oocytes—one from the mother and one from a donor—are fertilized and the nucleus from the zygote with malfunctioning mitochondria is transferred into the donor embryo. Robin Lovell-Badge ...

Researchers have for the first time succeeded in replacing defective mitochondrial genomes with healthy ones in monkey embryos--a technique that could be used to prevent children from inheriting a ...