Nature13 年
Endoplasmic reticulum stress and atherosclerosis
Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism ... but it gradually compromises macrophage function, driving the cells to stress, inflammation and ...
Frontiers4 年
Endoplasmic reticulum – shape and function in stress translation
You will be redirected to our submission process. The endoplasmic reticulum (ER) is a manufacturing unit in eukaryotic cells required for the synthesis of proteins, lipids, metabolites and hormones.
来自MSN1 个月
Endoplasmic reticulum model brings new insight to cell organelle's structure and function
The peripheral endoplasmic reticulum (ER) forms a continuous ... how the unique structure of the ER arises and supports its function is critical to developing a mechanistic understanding of ...
Nature7 年
Calreticulin: a Multifaceted Protein
A protein's function directly depends on its folded ... in the sarcoplasmic reticulum — a specialized type of endoplasmic reticulum found in muscle cells. Since calcium is essential for muscle ...
来自MSN1 个月
Computer simulations reveal how cells break down the endoplasmic reticulum
The endoplasmic reticulum functions as a reservoir for calcium and carbohydrates and also serves as the site for the synthesis of various hormones. Cells adjust the expansion and networking of ...
The Lancet7 年
Endoplasmic reticulum dysfunction in neurological disease
cCharles Darwin Department of Biology and Biotechnology and Institut Pasteur–Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy dINSERM U919, University of Caen Lower Normandy, ...
Invisible alliances: Kingdoms collide as bacteria and cells form captivating connections
In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is ...
Armed robbery in Revesby6 天
Bacteria and Cells Forge Fascinating Alliances
In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is ...
Frontiers1 个月
A stress paradox: the dual role of the unfolded protein response in the placenta
As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids. Central to these processes is the endoplasmic reticulum (ER), a dynamic ...
BMJ1 年
ABCG1 PLAYS AN IMPORTANT ROLE IN KEEPING ENDOTHELIAL FUNCTION ASSOCIATED WITH ENDOPLASMIC ...
It is reported that ABCG1 deficiency increases inflammatory responses in vascular EC and intracellular free cholesterol accumulation can activate endoplasmic reticulum stress (ERS ... There appears to ...
Helsinki3 年
Organelle Structure
The Jokitalo group studies structure-function interplay of organelles in mammalian cells. Our main model organelle is the endoplasmic reticulum. We employ a wide range of basic biological techniques ...