Secretory ASMase activation is required for ionizing radiation to kill endothelium (Santana et al., Cell 1996; 86:189-199), as endothelium in lung, gut, and brain are totally resistant to ...
Dysfunctional endothelium displays activation of vascular NADPH oxidase, uncoupling of endothelial nitric oxide synthase, increased expression of endothelin 1, a changed balance between the ...
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