Compounds that enhance enzyme activity show promise for cellular rejuvenation and treating age-related diseases. However, their development has proven challenging due to reliance on allosteric ...

How can we inhibit or activate enzymes? Pharmacological inhibition is carried out with a small molecule that chemists can optimize, which usually binds directly to the mouth, blocking the active site.

Innovative therapies revive a once-undruggable mitochondrial aging regulator through a revolutionary enzyme activation ...

Enzymes lower the activation energy necessary to transform a reactant into a product. On the left is a reaction that is not catalyzed by an enzyme (red), and on the right is one that is (green).

Researchers present novel therapeutics that rejuvenate a previously undruggable mitochondrial regulator of aging through a new mode of enzyme activation. Disclaimer: AAAS and EurekAlert!

Enzymes are primarily proteins, although some RNA molecules called ribozymes also exhibit enzymatic activity. Enzymes are biological catalysts that lower the activation energy of chemical reactions, ...

How does your body speed up these important reactions? The answer is enzymes. Enzymes in our bodies are catalysts that speed up reactions by helping to lower the activation energy needed to start a ...

This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...