Oxygenases have long been thought to require a cofactor for catalysis. The structure of a vancomycin biosynthetic enzyme in complex with a substrate analog, and with molecular oxygen bound in its ...

Researchers have discovered that an enzyme can serve as an ideal target for developing new therapeutics against Lyme disease, ...

By providing insights into the previously unknown function of the maturation enzyme HydF, these new findings may help to shed light on the biosynthesis of the unique cofactor of [FeFe]-hydrogenases.