A research team led by Dr. Martin Mollenhauer from the Heart Center at University Hospital Cologne has investigated the link ...

In a study published in Angewandte Chemie International Edition, a research team integrated activity-based protein profiling ...

Discover why BTK inhibitors have attracted interest for treating multiple sclerosis, as a few late-stage candidates close in ...

Researchers develop a caspase inhibitor that only works after being irradiated with UV light, giving them control over apoptosis in human cells. At Bessy II, a synchrotron radiation facility in Berlin ...

Study Objectives: To assess the clinical relevance of angiotensin-converting enzyme inhibitors (ACEI) and 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors (statins) in the context of ...

Inside cells, two important enzymes act like small central regulatory hubs: dipeptidyl peptidase 8 and 9—DPP8/9 for short.

Now, researchers have designed and synthesized new compounds that target the two enzymes. The new potential therapy is called ...

A Ludwig Cancer Research study has identified a novel strategy for treating acute myelogenous leukemia (AML), an aggressive ...

Other NSAIDs do not have this effect. Cox-2 inhibitors are a newer form of prescription NSAID. As you might guess, they only affect Cox-2 enzymes and not Cox-1. Two of them -- Bextra and Vioxx ...

Small-molecule enzyme-inhibitors often display insufficient affinity and selectivity for their targets causing unwanted side effects when used as drugs. Molecularly imprinted polymers prepared ...