Generations of students have been introduced to this subject with the first and second editions of Enzyme structure and mechanism by Alan Fersht. The detailed introductory descriptions of stopped ...

High resolution crystal structures of SF1 enzymes in complex with DNA and various nucleotide analogues have led to detailed proposals for ssDNA translocation through 'inch-worm' mechanisms that ...

Instead of the enzyme mechanism described in biochemistry text-books, hen lysozyme hydrolysis was postulated to occur by a ring-opening mechanism based on substrate interactions defined by the active ...

Enzymes, the core catalysts in life, drive critical biological processes ranging from metabolic regulation to energy ...

Life has evolved over billions of years, adapting to the changing environment. Similarly, enzymes—proteins that speed up ...

This important study shows, for the first time, the structure and snapshots of the dynamics of the full-length soluble Angiotensin-I converting enzyme dimer. The combination of structural and ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can ...

A study identifies senolytic compounds that can inhibit specific brain enzymes associated with Alzheimer’s disease (AD) while ...

Enzymes originally evolved in high-temperature environments and later adapted to lower temperatures as Earth cooled. Scientists discovered that a key shift in enzyme function occurred over ...

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional elongation enzymes during gene expression, findings that may inform the ...