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in a mouse model of KCNT1-related epilepsy. Durable seizure suppression and behavioral improvements were observed over 6 months, with favorable tolerability. The company plans to submit an ...
Hoffman et al, Disease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy, Science Translational Medicine (2025). DOI: 10.1126/scitranslmed.adt0527 ...