[20] as well as by the distribution of cofactors and corepressors of the estrogen-receptor complex within the tissue. [21] With estradiol as the standard, binding affinity for both estrogen ...

When treating patients with hormone-receptor positive, HER2-negative metastatic breast cancer, mutations necessitate the ...

According to the National Cancer Institute, roughly 15% of breast cancer cases are hormone-receptor negative, in which breast cancer cells do not contain hormone (estrogen or progesterone) receptors.