[20] as well as by the distribution of cofactors and corepressors of the estrogen-receptor complex within the tissue. [21] With estradiol as the standard, binding affinity for both estrogen ...

Binding of hormone to a hormone receptor can initiate a cell signalling cascade or promote changes in gene transcription. Depending on the type of hormone they bind, hormone receptors can be found ...

According to the National Cancer Institute, roughly 15% of breast cancer cases are hormone-receptor negative, in which breast cancer cells do not contain hormone (estrogen or progesterone) receptors.

When treating patients with hormone-receptor positive, HER2-negative metastatic breast cancer, mutations necessitate the ...

Triple-negative breast cancers are an aggressive form of disease that are negative for estrogen, progesterone, and the HER2 receptor proteins Informed by retrospective analysis of patient data and ...

[2] When studied separately from estrogen, the different progestin compounds have variable androgenic effect by their linkage with the androgenic receptor. On the other hand, progestins counter ...