Exons are coding sections of an RNA transcript, or the DNA encoding it, that are translated into protein. Exons can be separated by intervening sections of DNA that do not code for proteins ...

However, every exon does not circularize, and, in some cases, multiple exons are present in a circular RNA. We showed that repetitive elements, e.g. SINE elements, in the flanking introns are critical ...

and Cooper, T. A. (2014) RNA binding proteins in heart development. Adv Exp Med Biol. 825, 389-429. Pubmed Pedrotti, S. and Cooper, T.A. (2014) (Mis)-splicing in disease. J. Pathology 233,1-3. Pubmed ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Following successful development the bespoke Optimer binders will be used to precisely quantify the exon skipping activity of the RNA therapy. This quantification is essential to measure ...

Image Credit: Roche Sequencing and Life Science The KAPA Total Prep method can detect RNA fusions and exon-skipping events. The KAPA Total Prep FFPE technique was used to detect 16 RNA known ...

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