Exons are coding sections of an RNA transcript, or the DNA encoding it, that are translated into protein. Exons can be separated by intervening sections of DNA that do not code for proteins ...

In healthy cells, TRA2β levels are controlled by a built-in safety mechanism known as a poison exon. This small genetic ...

Ascidian Therapeutics, a biotechnology company seeking to treat human diseases by rewriting RNA, today announced the ...

The researchers focused on a genetic element known as a poison exon. This natural "off switch" prevents the production of certain proteins by marking their RNA messages for destruction before they ...

However, every exon does not circularize, and, in some cases, multiple exons are present in a circular RNA. We showed that repetitive elements, e.g. SINE elements, in the flanking introns are critical ...

Also in March 2025, Wave announced that the company met with the U.S. Food and Drug Administration (FDA) on WVE-N531 to ...

Image Credit: Roche Sequencing and Life Science The KAPA Total Prep method can detect RNA fusions and exon-skipping events. The KAPA Total Prep FFPE technique was used to detect 16 RNA known ...

An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.

For the treatment, a single adeno-associated virus is used to deliver the hfCas12Max and a guide RNA to the splice donor site of human exon 51. Scientists have previously completed preclinical studies ...