RNA stability or non-exon 9 splicing of PS1 in these families. Thus, there may be subtle phenotypic differences between Δ9Finn and Δ9 splice site mutations.

However, every exon does not circularize, and, in some cases, multiple exons are present in a circular RNA. We showed that repetitive elements, e.g. SINE elements, in the flanking introns are critical ...

In healthy cells, TRA2β levels are controlled by a built-in safety mechanism known as a poison exon. This small genetic ...

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They found their answer in antisense oligonucleotides (ASOs)—synthetic RNA fragments that can be designed to increase poison exon inclusion in specific ways. When introduced into cancer cells ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Image Credit: Roche Sequencing and Life Science The KAPA Total Prep method can detect RNA fusions and exon-skipping events. The KAPA Total Prep FFPE technique was used to detect 16 RNA known ...

Single exon deletions/duplications are present in ~0.45% of NF1-positive patients from the ... For novel NF1 variants of unknown significance, we offer free of charge targeted RNA-based testing to ...