by inactivating or creating a splice site. And more often than not, these mutations result in the exclusion of exons from mRNA, a process known as exon skipping. So finding a way to correct these ...

A large-scale effort to identify sequences involved in silencing exon and splice site usage sheds some new light on the properties of these poorly understood motifs and demonstrates the potential ...

Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...

“Combining the newer base editors with dual splice editing skipped the exon at a much better rate than we were previously able to with any of the available methods. We were able to show that not only ...

SPLICER uses a gene editing approach called exon skipping, which is of particular interest for health conditions caused by mutations that produce misfolded or toxic proteins, such as Duchenne's ...