Although LAT1 is a surface marker, the team used an antibody that recognizes an intra-exosomal region of the protein, requiring them to lyse the exosomes to confirm LAT1 expression. “If we can make ...

Evox is engineering exosomes—lipid-membrane-containing nanoparticles constitutively produced by cells—and loading them with protein therapeutics or nucleic-acid-based agents (Fig. 1).

They engineered them in a way that allowed them to carry cargo proteins fused with mMaple3, a photocleavable protein. This ...

Serum exosomes from a subset of participants were analyzed to concentrate low-level protein markers, including Aβ42 and p-tau proteins. No statistical differences were observed in exosome Aβ42 ...