Our brain requires a constant supply of energy. A disrupted energy supply, as, for instance, caused by a stroke, can have ...

ionophores, calcium chelators, as well as ligands for intracellular and extracellular receptors. "We had found a gene and the GPCR it encoded, ...

A new study shows that when energy is depleted—such as during a stroke—neurons begin releasing glutamate in abnormal, self-amplifying bursts that can damage nerve cells.

In regenerative science, B7-33's potential to influence fibroblast activity and collagen turnover suggests possible implications for tissue repair and wound healing. Given that fibrosis is often a ...

Receptors are shown as two lobes connected by a transmembrane stretch. Binding of a ligand, neuregulin (NRG, blue square) or something EGF-like to the extracellular lobe activates the receptors.

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G protein-coupled receptors (GPCRs) are involved in many diseases, yet raising therapeutic antibodies against them is notoriously difficult because the transmembrane receptors contain only short ...

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...